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Signal 2

INJ Matt Maiocco (X) SF Austen PleasantsOL Christian KirkWR De'Zhaun StriblingWR Isaac GuerendoRB Jake TongesTE Mykel WilliamsDL Nate HobbsDB Nick MartinLB Sam OkuayinonuDL 3d upd
49ers expected back from injury lists this season: DL Mykel Williams WR Christian Kirk CB Nate Hobbs LB Nick Martin OL Austen Pleasants RB Isaac Guerendo ??? DL Sam Okuayinonu WR De’Zhaun Stribling TE Jake Tonges
1 more updatefrom 1 source
- 3d Matt Maiocco (Bluesky) 49ers expected back from injury lists this season: DL Mykel Williams WR Christian Kirk CB Nate Hobbs LB Nick Martin OL Austen Pleasants RB Isaac Guerendo ??? DL Sam Okuayinonu WR De’Zhaun Stribling TE Jake Tonges+1
INJ Eric Branch (X) SF Alfred CollinsDL Mykel WilliamsDL Ricky PearsallWR Sep 8 upd
The #49ers' first draft pick in 2024 (Ricky Pearsall) is out for the season, their first pick in 2025 (Mykel Williams) is coming off a torn ACL and will miss at least the first four games and their second pick in 2025 (Alfred Collins) is out for the season.
1 more updatefrom 1 source
- Sep 8 Eric Branch (X) Forgot: Their third pick in 2025 (Nick Martin) is on injured reserve. · Quoting Eric Branch: The #49ers' first draft pick in 2024 (Ricky Pearsall) is out for the season, their first pick in 2025 (Mykel Williams) is coming off a torn ACL and will miss at least the first four games and their second pick in 2025 (Alfred Collins) is out for the season.
- Sep 8 Eric Branch (X) The #49ers' first draft pick in 2024 (Ricky Pearsall) is out for the season, their first pick in 2025 (Mykel Williams) is coming off a torn ACL and will miss at least the first four games and their second pick in 2025 (Alfred Collins) is out for the season.

The River 5

INJ ESPN NFL Injury Report SF Mykel WilliamsDL 6d
Mykel Williams (SF) DE -- Out
INJ ESPN NFL Injury Report SF Mykel WilliamsDL Sep 6
Mykel Williams (SF) DE -- Out
INJ ESPN NFL Injury Report SF Mykel WilliamsDL Sep 1
Mykel Williams (SF) DE -- Out
INJ David Lombardi (X) SF Mykel WilliamsDL Aug 31
The 49ers seriously considered activating Mykel Williams from PUP, since there's a chance he'll be ready to play before Week 5, but opted for the long-term play instead. Here's John Lynch's explanation:
INJ ESPN NFL Injury Report SF Mykel WilliamsDL Aug 30 upd
Mykel Williams (SF) DE -- Out
3 more updatesfrom 2 sources
- Aug 30 ESPN NFL Injury Report Mykel Williams (SF) DE -- Out
- Aug 30 Matt Maiocco (X) RB Isaac Guerendo and DL Mykel Williams begin the season on reserve/PUP. They are eligible to return to action after four games.+1
- Aug 30 Adam Schefter (X) 49ers placed DL Mykel Williams on the Reserve/Physically Unable to Perform List, meaning the former first-round pick will be sidelined for at least the first four games this season.